《I-Global Diabetes Map》
Cishe u-10% wabantu abadala unesifo sikashukela, kanti ingxenye yabo ayitholakali.
Umuntu oyedwa kwabayi-13 unokubekezelela i-glucose okungajwayelekile
Ingane eyodwa kweziyisithupha esanda kuzalwa ithintwa i-hyperglycemia ngesikhathi sokukhulelwa
Umuntu oyedwa ushona njalo ngemizuzwana engu-8 ngenxa yesifo sikashukela kanye nezinkinga zaso...
--------International Diabetes Federatio
Ukusabalala okuphezulu kwesifo sikashukela kanye nokufa okuphezulu
Umhla ziyi-14 kuLwezi wuSuku Lomhlaba Lwesifo Sikashukela.Balinganiselwa ezigidini ezingama-463 abantu abaphakathi kweminyaka engama-20 no-79 abaphila nesifo sikashukela emhlabeni wonke, iningi labo elinesifo sikashukela sohlobo lwesibili.Lokhu kulingana nomuntu omdala oyedwa kwabayi-11, ngokusho kwe-IDF's Diabetes Atlas yakamuva, uhlelo lwesishiyagalolunye lwe-International Diabetes Federation.
Okuthusa kakhulu ukuthi u-50.1% wabantu abadala emhlabeni abanesifo sikashukela abazi ukuthi banaso.Ngenxa yokuntuleka kokufinyelela ezinsizeni zezempilo, amazwe anemali ephansi anenani eliphezulu leziguli ezingakaxilongwa, ngamaphesenti angu-66.8, kuyilapho amazwe anemali engenayo ephezulu enamaphesenti angu-38.3 eziguli ezingakaxilongwa.
U-32% wabantu abanesifo sikashukela emhlabeni wonke banesifo senhliziyo nemithambo yegazi.Ngaphezu kwama-80% wesifo sezinso esisesigabeni sokuphela sibangelwa isifo sikashukela noma umfutho wegazi ophakeme noma kokubili.Izinkinga zonyawo kanye nezitho ezingezansi zithinta abantu abayizigidi ezingama-40 kuya kwezingama-60 abanesifo sikashukela.Cishe u-11.3% wokufa kwabantu emhlabeni wonke kuhlotshaniswa nesifo sikashukela.Cishe u-46.2% wokufa okuhlobene nesifo sikashukela bekuphakathi kwabantu abangaphansi kweminyaka engama-60.
Thayipha isifo sikashukela sohlobo 2 kanye nenkomba yesisindo somzimba ophezulu nakho kwandisa ingozi yomdlavuza ovamile: ohlanganisa isibindi, i-pancreatic, i-endometrial, i-colorectal kanye nomdlavuza wamabele.Njengamanje, ukwelashwa okuvamile kwesifo sikashukela ikakhulukazi ukwelashwa komuntu ngamunye ngezidakamizwa, ukuvivinya umzimba nokudla okufanele, futhi alikho ikhambi.
Insangu yezokwelapha 'inenhloso' yesifo sikashukela
Ucwaningo olusha olushicilelwe ku-Journal JAMA Internal Medicine lubonisa ukuthi izidakamizwa ezisekelwe insangu ziyasebenza ekwehliseni izimpawu kumagundane anesifo sikashukela.Ocwaningweni, izehlakalo zamagundane anesifo sikashukela asebenzisa insangu zehla zisuka ku-86% zaya ku-30%, futhi ukuvuvukala kwamanyikwe kwavinjwa futhi kwabambezeleka, kwadambisa ngempumelelo ubuhlungu bezinzwa.Ocwaningweni, ithimba lithole umphumela omuhle wensangu yezokwelapha kushukela:
01
# Lawula imetabolism #
I-metabolism ehamba kancane isho ukuthi umzimba awukwazi ukucubungula amandla ngokuphumelelayo, ukhinyabeza imisebenzi eyisisekelo, okuhlanganisa nokulawulwa kokushukela egazini, futhi kuholela ekukhuluphaleni.Amafutha amaningi emzimbeni anciphisa ukuzwela kwamangqamuzana egazi ku-insulin, okuphazamisa amandla awo okumunca ushukela, owaziwa nangokuthi ukumelana ne-insulin.Ucwaningo selukhombisile ukuthi iziguli ezisebenzisa insangu yezokwelapha zinokumelana ne-insulin okuphansi kanye ne-metabolism esheshayo, ekhuthaza "ukugcotshwa kwamafutha" futhi kusize amangqamuzana amhlophe aguquke abe amaseli ansundu.
i-metabolized futhi isetshenziswe njengamandla phakathi nomsebenzi womzimba ngaleyo ndlela ikhuthaze usuku lonke
ukunyakaza kanye ne-metabolism yamaseli emzimbeni.
02
# Ukumelana ne-insulin ephansi #
Lapho amangqamuzana egazi engazweli ku-insulin, ayahluleka ukukhuthaza ukuthuthwa kweglucose kumaseli, okuholela ekwakhekeni kweglucose.Insangu yezokwelapha inamandla okuthuthukisa ikhono lomzimba lokumunca nokusebenzisa i-insulin ngendlela efanele.Ucwaningo lwango-2013 olwanyatheliswa kuyi-American Journal of Medicine lwahlaziya abantu abadala abangu-4,657, kokubili amadoda nabesifazane, futhi bathola ukuthi iziguli ezivame ukusebenzisa insangu yezokwelapha zancipha ngamaphesenti angu-16 emazingeni e-insulin okuzila ukudla kanye nokunciphisa ngamaphesenti angu-16 ekuphikisweni kwe-insulin.
03
# Yehlisa ukuvuvukala kwamanyikwe #
Ukuvuvukala okungamahlalakhona kwamaseli e-pancreas kuwuphawu lwakudala lwesifo sikashukela sohlobo 1, lapho izitho zivuvukala, azikwazi ukukhulula i-insulin.I-marijuana yezokwelapha iphumelela ekunciphiseni ukuvuvukala, ukunciphisa ukuvuvukala, kanye nokwengeza okuqhubekayo kunganciphisa ubukhulu bokuvuvukala ku-pancreas futhi kusize ukubambezela ukuqala kwesifo.
04
# Thuthukisa ukuhamba kwegazi #
I-hypertension engapheli iyinkinga evame kakhulu yohlobo 1 nohlobo 2 sikashukela.Insangu yezokwelapha inganweba imithambo yegazi, ikhuthaze ukugeleza kwegazi emithanjeni, ilawule kangcono umfutho wegazi, futhi ivimbele umfutho wegazi ophakeme.
Ngo-2018, kwakhishwa umbiko nge-Convention on Biological Diversity, okusho ngokusobala ukuthi i-CBD iyinto yemvelo nephephile futhi akukho okungenzeka ukuhlukumeza.Ngisho nangemithamo efinyelela ku-1,500 mg ngosuku, ayikho imiphumela emibi.Ngakho-ke, ingabe insangu yezokwelapha iphephile ukwelapha isifo sikashukela?Ukusebenzisana kwezidakamizwa okungenzeka kucatshangelwe lapha.I-CBD ingase ibe nokuguquguquka okuncane komlomo owomile kanye nesifiso sokudla lapho ihlangana neminye imithi kadokotela, kodwa lezi ngokuvamile azivamile.
Yimuphi umthamo onconyiwe we-CBD wesifo sikashukela?I-US Food and Drug Administration (FDA) ayizange inikeze impendulo ecacile kulo mbuzo, ngoba ukuqina komzimba womuntu ngamunye, isisindo somzimba, ubudala, ubulili, kanye nokugayeka kokudla emzimbeni ngezinye zezinto eziningi ezinethonya.Ngakho-ke, isiphakamiso esivamile ukuthi iziguli ezinesifo sikashukela ziqala ngokusetshenziswa komthamo ophansi wokuhlolwa nokulungiswa komthamo kusenesikhathi.Iningi labasebenzisi ngeke lidlule ama-milligrams angama-25 wokuthathwa kwansuku zonke kwe-CBD, futhi ngaphansi kwezimo ezithile, umthamo olungile we-100 mg kuya ku-400 mg.
I-CB2 agonist -caryophyllene BCP iyasebenza ohlotsheni 2 sikashukela
Abacwaningi baseNdiya basanda kushicilela iphepha ku-European Journal of Pharmacology elibonisa umphumela we-CB2 agonist -carbamene BCP kuhlobo lwesifo sikashukela sohlobo 2.Abacwaningi bathola ukuthi i-BCP ivula ngokuqondile isamukeli se-CB2 kumaseli e-beta akhiqiza i-insulin kumanyikwe, okuholela ekukhululweni kwe-insulin nokulawula ukusebenza okuvamile kwamanyikwe.Ngesikhathi esifanayo, ukusebenza kwe-BCP kwe-CB2 kunomphumela omuhle ezinkingeni zesifo sikashukela, njenge-nephropathy, i-retinopathy, i-cardiomyopathy kanye ne-neuropathy. imifino eluhlaza okumnyama, enamaqabunga.)
# I-CBD inyusa ukukhiqizwa kwe-insulin ngokuvula i-receptor yezintandane i-GPR55 #
Abacwaningi baseBrazil abavela eNyuvesi yaseCalifornia, eMarin, bafunde imiphumela yezempilo ye-CBD kumodeli yezilwane ye-ischemia yesifo sikashukela.Abacwaningi bafaka uhlobo lwesifo sikashukela sohlobo 2 kumagundane abesilisa futhi bathola ukuthi i-CBD ibe nomthelela omuhle kushukela ngokwandisa i-plasma insulin.
I-CBD ingehlisa ushukela wegazi kumagundane ngezimo eziya ziba zimbi ngenxa yokuntuleka komoyampilo.Indlela yokusebenza kucatshangwa ukuthi i-CBD ingakhuphula ukukhiqizwa kwe-insulin ngokuvula i-GPR55 yezintandane. Nokho, Ikhono le-CBD lokunciphisa umsebenzi we-CB1 (njenge-negative allosteric regulator) noma amandla ayo okwenza i-PPAR receptor isebenze ingase futhi ithinte i-insulin. khulula.
Insangu yezokwelapha ingase isetshenziselwe ukwelapha umdlavuza, ukucindezela isithuthwane, i-neurology, namajaqamba emisipha, nokulawula ubuhlungu.Lokhu kuzothuthukisa ukukhula, njengoba imakethe yensangu yezokwelapha emhlabeni wonke kulindeleke ukuthi ifinyelele ku- $ 148.35 billion ngo-2026, ngokusho kwamaqiniso akamuva.《Imibiko kanye nedatha》.
Isikhathi sokuthumela: Dec-04-2020